Messenger RNA, or mRNA, vaccines work by instructing a small number of a person’s cells to make specific proteins. In the case of the approved mRNA vaccines for COVID-19, the cells make spike protein — one component of the virus that causes COVID-19.
For mRNA vaccines to work, it’s not enough to just put mRNA molecules into a vial and then inject them into a person’s muscle. One innovation that made the current mRNA vaccines possible was the use of lipids to encircle the mRNA molecules.